The answer to this question depends on the specific situation. If the size difference is minimal, then yes, you can run two different size tires on the same axle. However, if the difference is substantial, you should take special care to match the size of the tires on both axles. Mixing tire sizes can compromise your vehicle’s performance. Especially if you are trying to make an emergency stop.
The first question you should ask is what kind of tires you want to install. Tires come in two sizes, and putting one of them on the axle will cause uneven tire wear. Another important question to ask is what type of differentials your vehicle has. If the differentials are bad, the difference in tire sizes will affect the transmission. If you run two different size tires on the same axle, you can cause your vehicle to stall.
Normally, people mix the same size tires on the same axle. They can also use a spare tire, if one of the tires has blown out. This can also be a good idea if you need to change a tire in an emergency situation. However, you should keep in mind that mismatched tires can cause uneven tire wear and may even damage your car in the long run.
Using smaller tires on the same axle can cause damage to your transfer case and diff. Smaller tires will spin faster than bigger tires, which will cause the transfer case to be strained. Smaller tires will also cause your vehicle to lose traction. The solution is to install a spare tire that is at least as large as the smaller tires. And this is something most people don’t think about.